Early interventions

When it comes to relieving knee pain, there are many different treatment options. For some people, early intervention treatments like the ones below may help restore knee function.


Both prescription and over-the-counter medications can be used to treat the symptoms of osteoarthritis and control pain. Commonly used medications include but are not limited to aspirin-free pain relievers, anti-inflammatory drugs, corticosteroids, and sleep medications when pain prevents or interferes with sleep.

Low-impact exercise

Regular low-impact exercise, including joint and muscle exercises, can improve strength and flexibility. A common myth is that exercise will “wear out” joints, however, when done properly, low-impact exercise, such as walking or jogging, may actually reduce pain and fatigue and increase movement.

Heat/cold therapies

The use of heat or cold over joints may provide short-term relief from pain and stiffness. Cold packs can help reduce inflammation and swelling, and may be useful for flare-ups. Heat can aid in relaxing muscles and increasing circulation.

Weight management

 Weight loss helps to ease pain by reducing the amount of stress on your joints. After all, your knees bear the full load of your weight plus everything you carry. According to the Arthritis Foundation, every pound of excess weight applies about four pounds of extra pressure to your knees.2

Physical and occupational therapy

Physical therapists can work with you to create a personalized exercise program and show you how to use therapeutic heat and massages to potentially reduce pain. In addition, occupational therapists can introduce you to beneficial devices, such as those used to elevate chair or toilet-seat height.

Assistive devices

You can protect your knees by using a cane or other walking aid to keep from putting excess stress on them. Shoe inserts called orthotics are designed to support, align, and improve the function of your foot. In turn, they may lessen the pressure on your knees.


Different types of braces may help reduce knee pain and improve function and mobility. A "support" brace supports the entire load on your knee, and an "unloader" supports the weight on only one side of the knee, when only one side of the knee is damaged.


If these therapies don't work for you, you might be a candidate for treatment with Gel-One Hyaluronate.

Indications for use
Gel-One Hyaluronate is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to non-pharmacologic therapy, non-steroidal anti-inflammatory drugs (NSAIDs) or simple analgesics, e.g., acetaminophen.

Important safety information
Before using Gel-One Hyaluronate, tell your doctor if you are allergic to hyaluronan products, cinnamon, or products from birds such as feathers, eggs, and poultry. Gel-One Hyaluronate is only for injection into the knee, performed by a doctor or other qualified health care professional. You should not receive Gel-One Hyaluronate injection if you have a skin disease or infection around the area where the injection will be given. Gel-One Hyaluronate has not been tested to show pain relief in joints other than the knee and for conditions other than OA. Gel-One Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. You should tell your doctor if you think you are pregnant or if you are nursing a child. Talk to your doctor before resuming strenuous or pro-longed weight-bearing activities after treatment. The effectiveness of repeat treatment cycles of Gel-One Hyaluronate has not been established. The side effects most commonly seen after injection of Gel-One Hyaluronate in the clinical trial were knee pain, swelling, and/or fluid build-up around the knee. These reactions are generally mild and do not last long. If any of these symptoms or signs appear after you are given Gel-One Hyaluronate or if you have any other problems, you should call your doctor. Ask your surgeon if you are a candidate and discuss potential risks. For additional information, call 1-800-447-5633 , or visit www.zimmerbiomet.com.

This material is intended for U.S. patients.

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The information herein is of a general nature and does not represent or constitute medical advice or recommendations and is for general education purposes only. This information is not meant to replace the specific verbal and written recommendations and instructions provided by your surgeon for your specific situation. Patient treatment plans and outcomes will vary.

Results may vary.  Not all patients are candidates for this product and/or procedure. Only a medical professional can determine the treatment appropriate for your specific condition.  Appropriate post-operative activities and restrictions will differ from patient to patient. Talk to your surgeon about whether joint replacement is right for you and the risks of the procedure, including the risk of implant wear, loosening, or failure.