Gel-One® Single-injection Knee Treatment

If osteoarthritis (OA) knee pain is limiting your active lifestyle, you’ve come to the right place for answers.

From basketball, to cycling, to running, we understand knee pain caused by OA can keep you on the bench. That’s why Zimmer Biomet offers Gel-One Cross-linked Hyaluronate — a low-volume, single-injection treatment designed to help you get moving again.

If you have knee arthritis pain, Gel-One may provide relief so you can get back to doing what you love most. Talk to your doctor and find out if it’s time to ease your knees with Gel-One.

What is Gel-One?

Gel-One Cross-linked Hyaluronate is a transparent, sterile, and viscoelastic gel made from sodium hyaluronate (hyaluronan).

Hyaluronan is a natural substance found in high amounts in synovial joints. It acts like a lubricant and shock absorber in the joint and is needed for the joint to work properly.

What is viscosupplementation?

Viscosupplementation, sometimes called simply a “knee shot,” is a treatment for osteoarthritis (OA) of the knee in which an injection of sodium hyaluronate is delivered directly into the joint space. Viscosupplementation has been known to relieve pain associated with OA of the knee. There are many different viscosupplements available; Gel-One Cross-linked Hyaluronate is one option.

Why choose Gel-One?

Intra-articular (into the joint) viscosupplementation has been available in the U.S. market for a number of years. Gel-One is the first to offer a convenient single-injection “knee shot” treatment with a low volume of only 3mL.

Knee Diagram

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How Gel-One Knee Injections Work

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Gel-One FAQs

A: Gel-One is a transparent, sterile, and viscoelastic gel made from sodium hyaluronate (hyaluronan). Hyaluronan that is used to make Gel-One comes from rooster combs and is highly purified. Hyaluronan is also a natural substance found in the human body and is present in very high amounts in joints. The body’s own hyaluronan acts like a lubricant and shock absorber in the joint and is needed for the joint to work properly. Osteoarthritis (OA) is a condition that involves the wearing down of cartilage (the protective covering on the ends of your bones). In joints with OA, there may not be enough hyaluronan, and there may be lower quality of hyaluronan in joint fluid and tissues. Gel-One Hyaluronate is available in a 3.0 mL (approximately ½ teaspoon) pre-filled syringe. Gel-One Hyaluronate is injected directly into your knee joint and is a nonsurgical treatment for knee arthritis pain.

A: Gel-One is indicated for patients who do not respond adequately to other available treatments for knee osteoarthritis such as non-steroidal anti­inflammatory drugs (NSAIDS) or from simple pain medications, such as acetaminophen, or from exercise and physical therapy. Talk with your doctor to see if this treatment might be right for you.

A: In clinical studies, Gel-One has shown to reduce OA knee pain for up to 26 weeks. In addition, patients receiving multiple treatment cycles of Gel-One showed no increased risk of side effects.1-3

A: You and your doctor should discuss all medications that you are taking prior to beginning treatment with Gel-One.

A: Common side effects (also called reactions) are sometimes seen when Gel-One is injected into the knee joint. These can include: knee pain; swelling; and/or fluid build-up around the knee. These reactions are generally mild and do not last long. Reactions are generally treated by resting and applying ice to the injected knee. Sometimes it is necessary to give pain relievers by mouth, such as acetaminophen or NSAIDs, or to give injections of steroids, or to remove fluid from the knee joint.

If any of these symptoms or signs appear after you are given Gel-One Hyaluronate or if you have any other problems you should call your doctor.

A: Gel-One is given as a single injection directly into the joint space. Your doctor may recommend the use of a local anesthetic to reduce possible discomfort associated with an injection.

A: For 48 hours after you receive the injection, avoid any strenuous activities (such as jogging, tennis, other active sports, heavy Iifting) and prolonged weight bearing activities (such as standing on your feet for more than one hour).

A: Every patient responds differently to the treatment, but medical studies have shown that some patients experienced a reduction in pain in as little as three weeks after the injection of Gel-One.1-3

A: When it comes to relieving knee pain, there are many different treatment options. For some people, early intervention treatments such as medication, low-impact exercise, heat/cold therapies, weight management, physical and occupational therapy, assistive devices, bracing, or knee injections (corticosteroid or hyaluronic) may help restore knee function and reduce pain.

If nonsurgical knee treatments fail to relieve your pain and loss of mobility, your doctor may recommend a surgical procedure such as knee replacement surgery. Together, you and your doctor can determine the best treatment options for you.

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Insurance Coverage

If needed, a Zimmer Biomet specialist can support you through the insurance coverage process. Please contact us at 1-866-946-0444 or at

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